IDET - Innovazione Diagnostica e Terapeutica

Sectors

• Life Sciences und Materials
  • Biotechnology
  • Diagnostics

Services

• Research and Development
  • Research and Development inside the park
  • Administration of external research projects
• Human Resources
  • Organisation of conferences, courses and seminars
  • Staff training
  • Staff recruiting
  • Partnerships with universities and other research institutes

Other services

The activity of the centre is strongly marked by the use of technologies, which are used for the analysis des genome and the transcriptome (Affymetrix-Platform ) and the protein-protein or protein-ligand-interaction (plasmon resonance technology [BIAcore ]). These special technologies were not avaiable until recently to the public and private research groups and the industrial companies located in East Lombardy. Today, however, they are part of everyday research and personnel trained specifically for this can meet the requirements of numerous research groups. Thus, above all, a contribution to technological development of East Lombardy has been made, also to that of Italy.
The foundation of a "zebra fish laboratory" is certainly not only regionally of great significance. It is currently among only a few laboratories overall in Italy, which are active in this strategic biotechnological sector and provide innovative animal models for the investigation of human illnesses.

Data and Facts

Key data

• Founded in: 2001
• Number of departments: 2 1) Department for biomedical science and biotechnologies: subject areas Biology and Genetics, Pharmacology, Toxicology and Experimental Therapy and General Pathology and Immunology. 2) Department for Mother/Child and Biomedical Technologies: Subject areas: Obstetrics and Gynaecology and Paediatrics.
• Instruments: Laboratory for the investigation of embryonic development of the zebra fish (danio rerio); Laboratory for confocal microscopy; Plasmon resonancez (BIAcore); Affymetrix platform for the analysis of genomics and transcriptomics; Animal room for small animals and KO mice; P3-Laboratory for GMO research; Laboratory for radio isotopes application.
• Total Number of Employees: 66
• Area for research facilities: 1.500 m²
• Total area: 2.000 m²

Corporation

Predominantly academic

Sponsor

• Fundation: Fondazione Nocivelli presso gli Spedali Civili di Brescia
• Institute: Istituto Clinico Humanitas IRCCS, Rozzano, Milano

Objectives

• Attracting investors
• Enhancement of the competitiveness of companies
• Intensification of relations between universities and companies
• Build-up of new research activities
• Enhancement of the technology level of companies and institutions
• Technological consulting for companies and institutions
• Creation of new jobs
• Foundation of new companies
• Economic exploitation of the scientific results
• Enhancement of job quality
• Site support

Location

Location and Environment

Infrastructure and links

Other important infrastructure

The technological and inter-disciplinary service performed by the University of Brescia. This structure enables a direct interaction with researchers in the engineering, biotechnology and economics fields. It is expected that this interaction will throw light upon new perspectives for technological development and industrial transfer, which are of particular significance in East Lombardy.

Technology transfer

Inclusion in EU project

• 6° Programma quadro

National projects

• MIUR
• Fondazione Cariplo

Projects with Italian and Foreign Companies

• Project "Screening von antiangiogenetischen Präparaten"
• Project "Characterisation of teh activity and the effect mechanism of C5aR inhibitors and of dual CXCR1 and C5aR inhibitors"
• "Molecular Aspects of the inflammation-inhibiting activity of DF1681: Definition both of a cell model for the identification of a molecular target and also the effects expressed on the Transcriptome Project and on that, wich is induced by IL-8 in neutrophil granulocytes”
• "Evaluation of the Effects of the of the IL6-Chimera on Cells and Animal Models with regard to Neuro-Protection and Remyelination” Project

International patents:

These Projects have facilitated the depositing of the following international patents:

• Procedure for the identification of links, the regulation of immune and inflammation responses and their therapeutic application
• PTX3 as early marker for heart and brain blood vessel illnesses
• 6RIL6-Chimera for the treatment of neurovegetative illnesses
• Application of long Pentraxin PTX3 for the preparation of a preparation for the treatment of cancer illnesses, which are connected with a changed activation of the growth factor FGF2
• Application of long Pentraxin PTX3 for the preparation of a medical preparation for the treatment of cancer illnesses, which are connected with a changed activation of the growth factor FGF8
• Application of sulphated bacterial polysaccharides suitable for the inhibition of the angiogenesis
• The cell adhesion protein Jam as a target for the development of new therapeutic inoculation strategies

Contacts to Germany already exist

No

Contacts to German companies are welcomed in the (following) areas

Medicinal biotechnologies in immunology, oncology, molecular and genomic genetics and in neurosciences.

Research and Development

Research Projects:

• New inflamation molecules
• Identification of new endothelial-specific genes, whcih occur in angiogenesis and blood vessel tumors
• Identification of new molecules, which are involved in neuroal death
• Molecular medicine in genetic illnesses
• Gene characterisation and expression in genetic diseases and in amnio cells: diagnostic and therapeutic applications
• Molecular medicine of solid gynaecological tumors
• Analysis of the genomes in psychiatric illnesses
• Software development for the analysis of the genomes

Description

Technologies Used: IDET concentrates on the use of technologies for the analysis of the genomes, the transcriptome (Affymetrix –Plattform) and the protein-protein or protein-ligand-interaction (plasmon resonance technology [BIAcore]). Development of new software for the analysis of the genome, for the geno type determination and the analysis of the transcriptome.

Aim

Advantages: Development of new technologies and molecules with diagnostic and therapeutic applications in immunology, oncology, molecular genetics and the neurosciences.

Incubator and Incentives